Related Experiment Video
Updated: Feb 7, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
Evaluation of Injectable Chitosan-based Co-cross-linking Hydrogel for Local Delivery of 188Re-LIPO-DOX to
Feng-Yun J Huang1, Cheng-Chien Hung2, Chien-Wen Chang3
1Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.
Background/Aim:
An injectable chitosan-based co-cross-linking thermosensitive hydrogel combining 188Re- and doxorubicin-encapsulated liposomes (C/GP/GE/188Re-LIPO-DOX) was developed for the prevention of locoregional recurrence after mastectomy.
Materials And Methods:
The hydrogel properties, in vitro drug release characteristics, and in vivo scintigraphy imaging attributes were investigated.
Results:
The gelation time of the hydrogels can be controlled to be within 5 min. Results from Fourier-transform infrared spectroscopy, scanning electron microscopy, and dynamic mechanical analysis showed that a covalent cross-linking reaction between chitosan and genipin occurred and that the hydrogel's mechanical strength and chemical stability were improved. In vitro drug release studies showed that the hydrogel can prolong the release of doxorubicin by several weeks (51.5%±5.3% at 21 days). In addition, in vivo scintigraphy results suggested high retention rates (43.1%±1.0% at 48 h) of the radiopharmaceutical compound at the tumor injection site.
Conclusion:
The preliminary results indicated that the C/GP/GE/188Re-LIPO-DOX radiopharmaceutical hydrogel is a potential candidate for further in vivo therapeutic evaluation.
More Related Videos
09:39Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
Published on: June 1, 2012
13:43Intraductal Delivery and X-ray Visualization of Ethanol-Based Ablative Solution for Prevention and Local Treatment of Breast Cancer in Mouse Models
Published on: April 1, 2022
Related Concept Videos
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Crossing Over
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
Crossed Aldol Reaction Using Weak Bases
Collar Bearings
Bearing Stress
Due to the intricacy of these microforces, an average value, known as bearing stress, is often used by...
Azimuths and Bearings