Related Experiment Video

Updated: Feb 7, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
09:38

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

8.4K

Phase I Study Evaluating the Combination of Afatinib with Carboplatin and Pemetrexed After First-line EGFR-TKIs

Satoshi Watanabe1, O U Yamaguchi2, A I Masumoto2

  • 1Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Anticancer Research
|August 1, 2018
PubMed
Abstract

Insights

Afatinib combined with carboplatin and pemetrexed showed good clinical efficacy in EGFR-mutated non-small-cell lung cancer patients. The recommended dose of 20 mg/day afatinib was well tolerated, with a 30% overall response rate.

Area of Science:

  • Oncology
  • Pharmacology
  • Medical Research

Background:

  • Previous studies explored first-generation EGFR-TKIs with chemotherapy.
  • No prior analysis investigated afatinib with platinum-doublet chemotherapy.

Purpose of the Study:

  • To assess the safety and efficacy of afatinib combined with carboplatin and pemetrexed.
  • To determine the recommended dose for this combination therapy in EGFR-mutated NSCLC patients post-first-generation EGFR-TKI progression.

Main Methods:

  • A study involving ten EGFR-mutated non-small-cell lung cancer (NSCLC) patients.
  • Patients received varying doses of afatinib (20 or 30 mg/day) along with carboplatin and pemetrexed.
  • Safety and antitumor efficacy were evaluated.

Main Results:

  • Recommended afatinib dose identified as 20 mg/day due to dose-limiting toxicities at higher doses.
  • Observed dose-limiting toxicities included diarrhea, hypokalemia, elevated serum amylase, and thrombocytopenia.
  • Achieved an overall response rate of 30% and a median progression-free survival of 13.7 months.

Conclusions:

  • This is the first study to evaluate the combination of afatinib, carboplatin, and pemetrexed.
  • The combination therapy, at the recommended dose, demonstrated good tolerability.
  • The regimen showed promising clinical efficacy in the studied patient population.
Keywords:
AfatinibEGFR mutationcarboplatinnon-small-cell lung cancerpemetrexed

More Related Videos

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

3.4K
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K

Related Concept Videos

Phase Diagrams02:39

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.3K
Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.2K
Inductance: Single-Phase And Three-Phase Line01:28

Inductance: Single-Phase And Three-Phase Line

Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
633
Capacitance: Single-Phase And Three-Phase Line01:25

Capacitance: Single-Phase And Three-Phase Line

In electrical power systems, understanding the capacitance of transmission lines is fundamental for efficient operation.
Single-Phase Lines
Consider a single-phase, two-wire transmission line with equal phase spacing energized by a voltage source. One conductor carries a uniform positive charge, while the other carries an equal negative charge. The capacitance C of the line can be derived from the voltage V between the conductors. For a one-meter section of the line, the capacitance is given...
611
Phase Changes01:19

Phase Changes

Phase transitions play an important theoretical and practical role in the study of heat flow. In melting or fusion, a solid turns into a liquid; the opposite process is freezing. In evaporation, a liquid turns into a gas; the opposite process is condensation.
A substance melts or freezes at a temperature called its melting point and boils or condenses at its boiling point. These temperatures depend on pressure. High pressure favors the denser form of the substance, so typically, high pressure...
5.4K
Phase-lead and Phase-lag Controllers01:22

Phase-lead and Phase-lag Controllers

Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass...
574