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The plasma membrane is an essential cellular structure responsible for maintaining cellular integrity and regulating the selective transport of molecules. While bacteria and archaea share the fundamental function of plasma membranes, their structural and molecular differences reflect adaptations to distinct ecological and physiological challenges.Bacterial Plasma MembranesBacterial plasma membranes are predominantly composed of phospholipids with fatty acid chains ester-linked to a glycerol...
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Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
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Related Experiment Video

Updated: Feb 7, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
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Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

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Functional patchworking at the plasma membrane.

Sébastien Léon1, David Teis2

  • 1UMR 7592 Centre National de la Recherche Scientifique/Université Paris-Diderot, Institut Jacques Monod, Sorbonne Paris Cité, Paris, France.

The EMBO Journal
|August 1, 2018
PubMed
Summary
This summary is machine-generated.

Nutrient transporter activity influences protein movement within yeast plasma membrane microdomains. This suggests cells regulate protein localization to adapt to environmental changes.

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Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
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Area of Science:

  • Cell biology
  • Biochemistry
  • Molecular biology

Background:

  • Plasma membranes (PM) exhibit lateral heterogeneity, with lipids and proteins segregating into specialized microdomains.
  • The functional significance of this microdomain organization remains largely unclear.

Purpose of the Study:

  • To investigate the functional relevance of plasma membrane microdomains in cellular responses.
  • To determine if protein localization within microdomains is regulated by cellular activity.

Main Methods:

  • Utilized yeast as a model organism.
  • Investigated nutrient transporter behavior and localization within the plasma membrane.

Main Results:

  • Demonstrated that substrate flux through a nutrient transporter induces its lateral relocation between specific yeast PM microdomains.
  • Provided evidence for dynamic protein movement in response to transporter activity.

Conclusions:

  • Substrate flux-driven relocation suggests a mechanism for regulating protein compartmentalization within the plasma membrane.
  • This regulation of lateral plasma membrane compartmentalization may be a general cellular strategy for responding to environmental conditions.