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PedsQL 3.2 Diabetes Module for Children, Adolescents, and Young Adults: Reliability and Validity in Type 1 Diabetes
James W Varni1, Alan M Delamater2, Korey K Hood3
1Department of Pediatrics, College of Medicine, and Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, TX jvarni@tamu.edu.
Insights
The updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module shows excellent reliability and validity for assessing type 1 diabetes symptoms and management in young patients.
Area of Science:
- Pediatric Endocrinology
- Health Outcomes Research
- Psychometrics
Background:
- Type 1 diabetes impacts children and adolescents, necessitating reliable tools to measure quality of life.
- Existing quality of life measures require updates to reflect current understanding and patient needs.
Purpose of the Study:
- To evaluate the measurement properties of the revised Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module.
- To assess the reliability and validity of the PedsQL 3.2 Diabetes Module in a diverse pediatric population with type 1 diabetes.
Main Methods:
- A national field test involving 656 families of patients aged 2-25 years with type 1 diabetes.
- Utilized the PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales.
- Factor analysis was used to derive summary scores for diabetes symptoms and management.
Main Results:
- The Diabetes Symptoms and Diabetes Management Summary Scores demonstrated excellent reliability (Cronbach's alpha 0.88-0.90).
- Construct validity was supported by significant correlations with the Generic Core Scales (r = 0.43-0.67).
- HbA1c levels showed significant correlations with symptom and management scores (r = -0.21 to -0.29).
Conclusions:
- The PedsQL 3.2 Diabetes Module exhibits excellent measurement properties.
- This module can serve as a standardized patient-reported outcome for diabetes symptoms and management.
- It is suitable for use in clinical research, trials, and practice for pediatric type 1 diabetes populations.
Objective:
The objective of the study was to report on the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module for children, adolescents, and young adults with type 1 diabetes.
Research Design And Methods:
The 33-item PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were completed in a 10-site national field test study by 656 families of patients ages 2-25 years with type 1 diabetes.
Results:
The 15-item Diabetes Symptoms Summary Score and 18-item Diabetes Management Summary Score were derived from the factor analysis of the items. The Diabetes Symptoms and Diabetes Management Summary Scores evidenced excellent reliability (patient self-report α = 0.88-0.90; parent proxy report α = 0.89-0.90). The Diabetes Symptoms and Diabetes Management Summary Scores demonstrated construct validity through medium to large effect size correlations with the Generic Core Scales Total Scale Score (r = 0.43-0.67, P < 0.001). HbA1c was significantly correlated with the Diabetes Symptoms and Diabetes Management Summary Scores (r = -0.21 to -0.29, P < 0.001). Minimal clinically important difference scores ranged from 5.05 to 5.55.
Conclusions:
The PedsQL 3.2 Diabetes Module Diabetes Symptoms and Diabetes Management Summary Scores demonstrated excellent measurement properties and may be useful as standardized patient-reported outcomes of diabetes symptoms and diabetes management in clinical research, clinical trials, and practice in children, adolescents, and young adults with type 1 diabetes.
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