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Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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X-linked Traits01:19

X-linked Traits

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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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Behavior Modification01:21

Behavior Modification

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Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
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Updated: Feb 7, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

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Link Between m6A Modification and Cancers.

Zhen-Xian Liu1, Li-Man Li1, Hui-Lung Sun2

  • 1Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China.

Frontiers in Bioengineering and Biotechnology
|August 1, 2018
PubMed
Summary
This summary is machine-generated.

N6-methyladenosine (m6A) is a key RNA modification in eukaryotes. This review explores m6A regulators and their significant roles in cancer development, suggesting potential diagnostic and therapeutic targets.

Keywords:
cancersfunctionm6AmRNAstructures

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNAs (mRNAs).
  • m6A plays critical roles in mRNA metabolism and various biological processes.
  • Recent advancements in m6A sequencing have elucidated its molecular mechanisms and biological significance.

Purpose of the Study:

  • To review the characteristics of m6A regulators, including "writers", "erasers", and "readers".
  • To highlight the involvement of m6A modification in the development of various cancers.
  • To discuss the potential of m6A and its regulators as diagnostic and therapeutic targets for cancer.

Main Methods:

  • Literature review of m6A sequencing and related studies.
  • Analysis of the roles of m6A regulators in cancer biology.
  • Synthesis of current understanding of m6A mechanisms in oncogenesis.

Main Results:

  • m6A regulators ("writers", "erasers", "readers") govern mRNA fate and function.
  • m6A modification is implicated in key cancer processes like proliferation, migration, and invasion.
  • Dysregulation of m6A regulators contributes to the development of both solid and non-solid tumors.

Conclusions:

  • m6A modification is a crucial epitranscriptional mark with broad biological implications.
  • m6A regulators are significantly involved in cancer pathogenesis.
  • Targeting m6A pathways offers promising avenues for novel cancer diagnostics and therapeutics.