Related Experiment Video

Updated: Feb 7, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

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The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure

Najah Harouki1,2,3, Lionel Nicol1,2,3,4, Isabelle Remy-Jouet1,2,3

  • 1INSERM U1096, Rouen, France.

JACC. Basic to Translational Science
|August 1, 2018
PubMed

This study reports preclinical data showing that the interleukin (IL)-1β modulation is a new promising target in the pathophysiological context of heart failure. Indeed, in nondiabetic Wistar and diabetic Goto-Kakizaki rats with chronic heart failure induced by myocardial infarction, administration of the IL-1β antibody gevokizumab improves 'surrogate' markers of survival (i.e., left ventricular remodeling, hemodynamics, and function as well as coronary function). However, whether IL-1β modulation per se or in combination with standard treatments of heart failure improves long-term outcome in human heart failure remains to be determined.

Keywords:
GK, Goto-KakisakiI/R, ischemia/reperfusionIL, interleukinIL-1βLV, left ventricle/ventricularLVEDP, left ventricular end-diastolic pressureLVEDPV, left ventricular end-diastolic pressure–volume relationshipLVESP, left ventricular end-systolic pressureLVESPVR, left ventricular end-systolic pressure–volume relationshipROS, reactive oxygen speciesSOD, superoxide dismutasecardiovascular functionheart failureischemia/reperfusion

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