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Viral resistance, clinical experience.

D W Barry, S Nusinoff-Lehrman, M N Ellis

    Scandinavian Journal of Infectious Diseases. Supplementum
    |January 1, 1985
    PubMed
    Summary

    Acyclovir sensitivity in herpes simplex virus isolates remained stable over five years. While some viral resistance occurred, it rarely impacted treatment outcomes, except in severely immunocompromised patients with prolonged therapy.

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    Area of Science:

    • Virology
    • Antiviral Drug Resistance
    • Clinical Microbiology

    Background:

    • Herpes simplex virus (HSV) infections are common globally.
    • Acyclovir is a primary antiviral medication for HSV treatment.
    • Monitoring acyclovir resistance is crucial for effective HSV management.

    Purpose of the Study:

    • To assess changes in acyclovir sensitivity of HSV isolates over a five-year period.
    • To correlate in vitro acyclovir sensitivity with clinical outcomes in patients.
    • To evaluate the clinical significance of acyclovir-resistant HSV strains.

    Main Methods:

    • Analysis of over 1500 HSV isolates from 600+ patients.
    • Dye uptake method in Vero cells for acyclovir sensitivity testing.
    • Correlation of laboratory sensitivity data with patient clinical responses.

    Main Results:

    • No significant overall change in acyclovir sensitivity was observed in HSV isolates.
    • A small number of isolates showed diminished sensitivity during therapy.
    • Diminished sensitivity was occasionally linked to poor ulcer healing in severely immunocompromised patients receiving prolonged acyclovir treatment.

    Conclusions:

    • Acyclovir sensitivity in HSV isolates is generally stable.
    • In vitro resistance does not always predict clinical treatment failure.
    • Close monitoring is needed for severely immunocompromised patients undergoing long-term acyclovir therapy.

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