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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
The evolution of vaccines for early childhood: the MMRV
G Ferrera1, R Squeri2, C Genovese3
1Public Health Service, Epidemiology and Medicine, ASP Ragusa, Italy.
Abstract:
Measles, mumps, rubella and varicella vaccines have greatly reduced the incidence of these four childhood diseases, which in the past caused a considerable burden of morbidity and lethality to the population. Vaccines against MMR, varicella and a tetravalent MMRV vaccine are currently available on the market to provide immunization against measles-mumps-rubella and varicella. A recently passed Italian Law (L 119/2017) on vaccinations increased the number of free of charge but compulsory vaccinations from four to ten, including MMR and varicella, as a requirement for admission to nursery schools and kindergartens; fines may be levied for non compliance, in the attempt to increase vaccination coverage. The Italian National Immunization Program 2017-19 allows immunization to be administered either by: the trivalent anti-measles-mumps-rubella plus the monovalent anti-varicella vaccine, administered in different anatomic sites at the same session, or by a quadrivalent MMRV combined vaccine.
Insights
Measles, mumps, rubella, and varicella vaccines significantly reduce childhood disease. Italy
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- Measles, mumps, rubella, and varicella historically caused significant morbidity and mortality.
- Vaccines have dramatically decreased the incidence of these diseases.
- Available vaccines include MMR, varicella, and a combined MMRV vaccine.
Purpose of the Study:
- To outline the updated Italian National Immunization Program (2017-19) regarding MMR and varicella vaccination.
- To inform about new compulsory vaccination laws in Italy impacting school admissions.
- To detail vaccination administration options under the national program.
Main Methods:
- Review of the Italian Law L 119/2017 concerning compulsory vaccinations.
- Description of the Italian National Immunization Program 2017-19 vaccination schedules.
- Explanation of vaccine administration protocols for MMR and varicella.
Main Results:
- Italian Law L 119/2017 mandates ten vaccinations, including MMR and varicella, for nursery and kindergarten admission.
- Non-compliance with mandatory vaccinations may result in fines.
- The national program permits administration via separate trivalent MMR and monovalent varicella vaccines or a combined quadrivalent MMRV vaccine.
Conclusions:
- The updated Italian vaccination policy aims to increase vaccine coverage for MMR and varicella.
- Vaccination remains a critical public health strategy to control preventable childhood diseases.
- Flexible administration options are provided to facilitate immunization.
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