Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypothalamic factors: current findings].

P C Sizonenko

    Schweizerische Medizinische Wochenschrift
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Scientists have identified new hypothalamic peptides, growth-hormone releasing factor (GRF) and corticotrophin-releasing factor (CRF). Synthetic analogues of gonadotrophin-releasing hormone (GnRH) show promise for treating various conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Psychological evaluation of young women after medical treatment for central precocious puberty.

    Hormone research·2002
    Same author

    Diagnosis and management of growth hormone deficiency in childhood and adolescence. Part 1: diagnosis of growth hormone deficiency.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2001
    Same author

    Diagnosis of growth hormone deficiency in childhood. On behalf of the Growth Hormone Research Society.

    Hormone research·2000
    Same author

    A case of 45,X Turner syndrome with spontaneous ovulation proven by ultrasonography.

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
    Same author

    Human insulin induces a higher glucagon response to induced hypoglycemia in short normal children, compared to porcine insulin.

    Journal of pediatric endocrinology & metabolism : JPEM·1999
    Same author

    Should we monitor more closely the dosage of 9 alpha-fluorohydrocortisone in salt-losing congenital adrenal hyperplasia?

    Journal of pediatric endocrinology & metabolism : JPEM·1998
    Same journal

    Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Boeck's disease as a tuberculous syndrome.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Enteral primary tubercular complexes

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Tuberculous stenoses of the large bronchi.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    About the enzyme action.

    Schweizerische medizinische Wochenschrift·2010
    See all related articles

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Peptide Chemistry

    Background:

    • Recent years have seen the isolation, characterization, and synthesis of novel hypothalamic peptides.
    • Growth-hormone releasing factor (GRF) and corticotrophin-releasing factor (CRF) are key regulatory hormones.

    Purpose of the Study:

    • To review the isolation, characterization, and synthesis of GRF and CRF.
    • To explore the therapeutic potential of synthetic analogues of gonadotrophin-releasing hormone (GnRH).

    Main Methods:

    • Isolation and characterization of naturally occurring hypothalamic peptides.
    • Chemical synthesis of analogues of hypothalamic peptides, including GnRH agonists and antagonists.
    • Evaluation of the physiological effects of these peptides and their analogues.

    Related Experiment Videos

    Main Results:

    • GRF was isolated from pancreatic tumors causing acromegaly and found identical to hypothalamic GRF (1-44).
    • CRF specifically stimulates ACTH and beta-endorphin secretion from the pro-opiomelanocortin precursor.
    • GnRH agonists induce pituitary desensitization and decreased gonadotropin/sex steroid secretion, with therapeutic applications being investigated.
    • Pulsatile GnRH administration can restore reproductive functions.

    Conclusions:

    • Hypothalamic peptides GRF and CRF play crucial roles in endocrine regulation.
    • Synthetic GnRH analogues offer diverse therapeutic strategies for hormonal imbalances and reproductive disorders.