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Classical Protein Kinase C: a novel kinase target in breast cancer

R K Singh1, S Kumar1, M S Tomar1

  • 1Immunology lab, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 1, 2018
PubMed

Insights

Classical protein kinase C (cPKC) enzymes regulate cellular functions, but their dysregulation causes diseases like cancer. This review details cPKC structure, activation, and functions to aid breast cancer therapy development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Classical protein kinase C (cPKC) enzymes are crucial serine/threonine kinases regulating vital cellular functions.
  • Dysregulation of cPKC signaling contributes to various pathophysiological conditions, including cancer.
  • Understanding cPKC's role is essential for maintaining cellular homeostasis and preventing disease.

Purpose of the Study:

  • To provide a comprehensive review of classical protein kinase C (cPKC) enzymes.
  • To detail cPKC structure, activation mechanisms, regulation, and cellular functions.
  • To offer insights for developing therapeutic strategies against cPKC-related diseases, particularly breast cancer.

Main Methods:

  • Literature review focusing on cPKC structure, activation, regulation, and function.
  • Analysis of molecular mechanisms involved in cPKC-mediated signaling.
  • Synthesis of information on cPKC's role in cellular processes like growth, survival, migration, and adhesion.

Main Results:

  • cPKC enzymes are involved in diverse cellular functions, with roles varying by cell type and substrate.
  • Dysregulated cPKC activity can lead to cellular transformation and disease development.
  • Multiple molecular mechanisms, including phosphorylation and second messenger binding, regulate cPKC signaling.

Conclusions:

  • A detailed understanding of cPKC biology is currently lacking for effective therapeutic development.
  • This review consolidates information on cPKC to facilitate the design of therapeutic regimens.
  • Targeting cPKC pathways holds potential for treating diseases such as breast cancer.
Keywords:
Breast cancerCell adhesionCellular microenvironmentClassical protein kinase CEstrogen receptor

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