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Microparticles as autoantigens in systemic lupus erythematosus
Fariborz Mobarrez1, Elisabet Svenungsson1, David S Pisetsky2,3
1Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.
European Journal of Clinical Investigation
|August 1, 2018
Summary
Systemic lupus erythematosus (SLE) involves autoantibodies attacking cell nuclei. Microparticles (MPs) in SLE patients carry nuclear antigens, potentially driving disease and serving as biomarkers.
Area of Science:
- Immunology
- Autoimmunity
- Cell Biology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease marked by antinuclear antibodies (ANAs).
- Nuclear autoantigens in vivo are likely part of larger structures, not just purified molecules.
- Microparticles (MPs), released from cells or platelets, contain diverse intracellular components.
Purpose of the Study:
- To investigate the role of microparticles (MPs) in the pathogenesis of Systemic Lupus Erythematosus (SLE).
- To explore the potential of MPs as biomarkers for SLE.
Main Methods:
- Assessing MPs in blood and tissue culture media using flow cytometry.
- Biochemical analyses to determine MP composition.
- Flow cytometry to detect IgG-containing particles in SLE patients.
Main Results:
- Microparticles (MPs) contain nuclear, cytoplasmic, and membrane molecules, allowing ANAs to bind.
- Levels of MPs are elevated in the blood of SLE patients.
- Flow cytometry confirmed the presence of IgG-containing MPs in SLE patients.
Conclusions:
- MPs play a significant role in SLE pathogenesis by forming immune complexes and directly stimulating immune responses.
- MPs are valuable potential biomarkers for SLE diagnosis and monitoring.
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