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Hemagglutinating activity associated with bovine herpesvirus type 1
Veterinary Microbiology
|December 1, 1985
Summary
Bovine herpesvirus type 1 (BHV-1) strains, including field isolates, cause hemagglutination in mouse erythrocytes. Hemagglutination inhibition assays confirmed the specificity of this viral interaction.
Area of Science:
- Virology
- Immunology
Background:
- Bovine herpesvirus type 1 (BHV-1) is a significant pathogen in cattle.
- Understanding viral surface protein interactions is crucial for vaccine development and diagnostics.
Purpose of the Study:
- To investigate the hemagglutinating properties of BHV-1 strains.
- To confirm the specificity of BHV-1 induced hemagglutination.
Main Methods:
- Hemagglutination assays using C57BL/HPB mouse erythrocytes.
- Hemagglutination inhibition assays with BHV-1 strains and field isolates.
Main Results:
- Hemagglutination was observed with reference strains (Los Angeles, Colorado-1) and 12 Canadian BHV-1 field isolates.
- Hemagglutination inhibition assays confirmed the specificity of the observed hemagglutination.
Conclusions:
- BHV-1 strains possess hemagglutinating activity.
- This activity is specific and can be inhibited, suggesting potential for diagnostic applications.