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Weight effects of antidiabetic agents
Ashley M Higbea1, Courtney Duval1, Lisa M Chastain1
1a School of Pharmacy , Texas Tech University Health Sciences Center , Dallas , TX , USA.
Expert Review of Endocrinology & Metabolism
|August 1, 2018
Summary
When managing diabetes, consider how medications affect weight. Newer drugs like glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter 2 inhibitors aid weight loss, while others may cause weight gain or be neutral.
Area of Science:
- Endocrinology
- Pharmacology
- Metabolic Diseases
Background:
- Rising global prevalence of obesity and diabetes presents a significant health challenge.
- Antidiabetic medications have variable effects on body weight, necessitating careful consideration during treatment selection.
- Understanding these weight effects is crucial for optimizing diabetes management.
Purpose of the Study:
- To summarize current evidence on the weight effects of various antidiabetic agents.
- To inform clinical decision-making regarding the selection of antidiabetic medications.
- To highlight the differential impact of antidiabetic drugs on patient weight.
Main Methods:
- Literature review of guidelines, clinical trials, and meta-analyses.
- Searches conducted in PubMed and Ovid databases up to July 2017.
- Focus on weight effects of specific antidiabetic drug classes.
Main Results:
- Glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter 2 inhibitors are associated with weight reduction.
- Insulin, sulfonylureas, and thiazolidediones may lead to weight gain.
- Metformin and dipeptidyl peptidase-4 inhibitors are generally weight-neutral.
Conclusions:
- The weight effects of antidiabetic agents vary significantly.
- Clinicians should weigh potential risks (e.g., weight gain) against benefits (e.g., glycemic control) when prescribing.
- Informed selection of antidiabetic therapy can improve patient outcomes and adherence.
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