Related Experiment Video
Updated: Feb 7, 2026
08:53
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
1.8K
Computer-Assisted Compared with Conventional Total Knee Replacement: A Multicenter Parallel-Group Randomized
Gunnar Petursson1,2, Anne Marie Fenstad2, Øystein Gøthesen2,3,4
1Lovisenberg Diaconal Hospital, Oslo, Norway.
The Journal of Bone and Joint Surgery. American Volume
|August 1, 2018
Summary
Computer-assisted total knee replacement significantly improved pain and function compared to conventional surgery at two years. This technique led to more high responders, demonstrating better patient outcomes in total knee replacement procedures.
Area of Science:
- Orthopedic Surgery
- Medical Technology
- Clinical Trials
Background:
- Previous short-term results of computer-assisted vs. conventional total knee replacement (TKR) were reported.
- This study presents the 2-year clinical outcomes from the same randomized controlled trial (RCT).
Purpose of the Study:
- To compare the 2-year clinical outcomes of computer-assisted TKR versus conventional TKR.
- To evaluate patient-reported outcome measures (PROMs) and responder rates at 2 years post-surgery.
Main Methods:
- 190 patients were randomized to computer-assisted or conventional TKR.
- 172 patients completed 2-year follow-up, with 167 providing complete PROMs (KOOS, WOMAC, KSS, VAS, EQ-5D).
- Patients and evaluators were blinded; outcomes assessed using OMERACT-OARSI criteria.
Main Results:
- Computer-assisted TKR showed significantly greater improvement in KOOS symptom and sport/recreation scores, and WOMAC stiffness scores.
- The computer-assisted group had a higher rate of high responders (82.8% vs. 68.8%, p=0.03).
- Number needed to treat was 8 for computer-assisted TKR.
Conclusions:
- Computer navigation in TKR offers superior pain relief and functional restoration at 2 years compared to conventional techniques.
- This suggests computer-assisted surgery is a more effective approach for TKR patients seeking improved outcomes.
More Related Videos
14:45Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
Published on: September 16, 2012
15.5K
03:53Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
2.9K
Related Concept Videos
01:23Knee Joint
3.3K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.3K
01:30Sign Convention
3.5K
When analyzing a beam subjected to various loads, it is crucial to understand the internal forces and moments generated within the structure. These internal forces can be broadly classified into normal forces, shear forces, and bending moments. To determine these forces and moments, we use the method of sections and apply a specific sign convention based on their direction and the side of the section being analyzed.
The normal force acts perpendicular to the beam's cross-section and can...
The normal force acts perpendicular to the beam's cross-section and can...
3.5K
01:23Parallel Resonance
581
The parallel RLC circuit is an arrangement where the resistor (R), inductor (L), and capacitor (C) are all connected to the same nodes and, as a result, share the same voltage across them. The parallel RLC circuit is analyzed in terms of admittance (Y), which reflects the ease with which current can flow. The admittance is given by:
581
01:20Parallel Processing
733
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
733
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:12Trial and Error and Algorithm
424
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
424