Related Experiment Video
Updated: Feb 7, 2026
04:08
Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
1.1K
Early Surgical Stabilization of Complex Chest Wall Injuries Improves Short-Term Patient Outcomes.
Hafiz J Iqbal1, Joseph Alsousou1,2, Sohan Shah1
1Department of Trauma and Orthopaedics, Aintree University Hospitals NHS (National Health Service) Trust, Liverpool, United Kingdom.
The Journal of Bone and Joint Surgery. American Volume
|August 1, 2018
Summary
Surgical fixation of complex rib fractures improves patient outcomes. Early surgical intervention, within 48 hours, significantly reduces intensive care unit stays, complications like pneumonia, and overall hospital length of stay.
Area of Science:
- Trauma Surgery
- Orthopedic Surgery
- Critical Care Medicine
Background:
- Complex rib fractures pose significant management challenges in major trauma.
- Internal fixation is an option for severe cases, but outcomes require assessment.
Purpose of the Study:
- To evaluate the outcomes of patients undergoing surgical fixation for complex rib fractures.
- To determine the impact of timing of fixation on patient recovery.
Main Methods:
- Retrospective analysis of 102 patients undergoing operative rib fracture fixation between March 2014 and May 2016.
- Outcome measures included hospital length of stay, ICU admission, mechanical ventilation, infection, and mortality.
Main Results:
- Early fixation (within 48 hours) was associated with shorter ICU stays, reduced pneumonia rates, and decreased mechanical ventilation duration.
- Patients with additional injuries and those requiring mechanical ventilation had significantly longer hospital stays.
- A total of 102 patients underwent fixation, with 52% requiring ICU admission.
Conclusions:
- Surgical stabilization of multiple rib fractures can enhance outcomes for patients with polytrauma and isolated chest trauma.
- Performing surgical fixation early, within 48 hours of injury, leads to improved patient outcomes and shorter hospitalizations.
Related Concept Videos
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
855
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
855
01:53RNA Stability
35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
01:24Flail Chest-I
737
Overview of Flail Chest
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
Flail chest is a severe and potentially life-threatening condition characterized by the fracture of three or more adjacent ribs in multiple places. It is most commonly caused by direct impacts and trauma, such as motor vehicle accidents or injuries from a steering wheel impact. It can also occur due to falls in elderly individuals with osteoporosis, or assaults involving sharp objects.
Pathophysiology
The pathophysiology of flail chest is complex, involving fractures of...
737
01:26Flail Chest-II
648
Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:
Assessment:
1. Clinical Evaluation:
History:
648
01:24Chest Physiotherapy
1.8K
Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
1.8K
02:51mRNA Stability and Gene Expression
6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Cis-acting Elements involved in mRNA stability
6.7K