Cross-sectional validation of the PROMIS-Preference scoring system

Area of Science:

• Health Outcomes Research
• Psychometrics
• Health Economics

Background:

• The Patient-Reported Outcomes Measurement Information System (PROMIS) developed the PROMIS-Preference (PROPr) score.
• PROPr is a preference-based summary score for seven PROMIS domains, utilizing multi-attribute utility theory.
• It functions as a generic, societal, preference-based measure of health-related quality of life.

Purpose of the Study:

• To evaluate the construct validity of the PROMIS-Preference (PROPr) score.
• To assess PROPr's ability to reflect quality of life in general US population samples.
• To compare PROPr with other established health utility measures.

Main Methods:

• Two online panel surveys (PROPr Estimation Survey and Profiles-Health Utilities Index Survey) were used.
• Data included PROPr, demographic information, chronic conditions, and other preference-based scores (EQ-5D-5L, HUI).
• Known-groups validity was assessed via age/gender stratification and condition impact estimates; convergent validity used Pearson correlations.

Main Results:

• PROPr scores were generally lower than EQ-5D and HUI scores, indicating fewer perfect health scores.
• PROPr identified statistically significant impacts for all 11 assessed chronic conditions in one survey and all 21 in another.
• Correlations between PROPr and other summary measures ranged from 0.67 to 0.70, indicating good convergent validity.

Conclusions:

• The study provides evidence supporting the construct validity of the PROPr score.
• PROPr effectively differentiates health status based on demographic factors and chronic conditions.
• The findings support PROPr's utility as a generic, preference-based measure of health-related quality of life.