Related Experiment Video
Updated: Feb 7, 2026

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
Sika deer antler as a novel model to investigate dental implant healing: A pilot experimental study
Yun He1,2, Dominik Fischer3,4, Istabrak Hasan1,5
1Endowed Chair of Oral Technology, University of Bonn, Bonn, Germany.
Abstract:
Dental implants are important tools for restoring the loss of teeth. The rapid growth and periodic regeneration of antlers make Sika deer a good and less invasive alternative model for studying bone remodelling in mammals. We developed a special loading device for antlers and analysed the bone reaction around unloaded implants and under immediate loading conditions until osseointegration occurred. In micro-computed tomography images, the density of antler tissue around the implants increased as the loading time increased. This finding was histologically confirmed by the good osseointegration observed in unloaded and loaded specimens. Antler tissue displays a similar healing process to human bone. The use of an antler model is a promising alternative for implant studies that does not require animal sacrifice.
Related Concept Videos
Pilot and Numeric Relaying
Typical Model Studies
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Experimental Determination of Chemical Formula
Experimental RNAi

