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Human methionine synthase A2756G polymorphism increases susceptibility to prostate cancer

Hong-Bao Shao1, Kewei Ren2, Sheng-Lin Gao3

  • 1Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi 214041, China.

Aging
|August 1, 2018
PubMed
Abstract

Insights

The MTR gene A2756G polymorphism is associated with an increased risk of prostate cancer (PCa). Higher serum MTR levels were observed in PCa patients with specific genotypes, suggesting a potential diagnostic role.

Area of Science:

  • Genetics and Cancer Research
  • Molecular Biology
  • Epidemiology

Background:

  • Previous studies on the association between the MTR gene A2756G polymorphism and prostate cancer (PCa) risk have yielded inconclusive results.
  • Understanding genetic predispositions is crucial for PCa risk assessment and early detection.

Purpose of the Study:

  • To evaluate the correlation between the MTR A2756G polymorphism and PCa risk using a comprehensive meta-analysis.
  • To investigate the potential role of serum MTR levels in PCa diagnosis.

Main Methods:

  • A meta-analysis was conducted using odds ratios (ORs) and 95% confidence intervals (95% CIs) to assess the MTR A2756G polymorphism and PCa risk.
  • Serum MTR expression was measured using ELISA, and in-silico tools were employed to analyze the variant.
  • The study included 2,921 PCa patients and 3,095 control subjects.

Main Results:

  • The MTR A2756G polymorphism was significantly linked to an increased risk of PCa across three genetic models.
  • Stratified analyses and advanced PCa subgroup analysis corroborated these findings.
  • Serum MTR levels were statistically higher in PCa patients with AA genotypes compared to those with GG/GA genotypes.

Conclusions:

  • The MTR A2756G polymorphism may contribute to PCa risk, especially in Asian and hospital-based populations.
  • Serum MTR levels show potential as a biomarker for PCa diagnosis.
Keywords:
ELISAgenetic variationmethionine synthasepolymorphismprostate cancer

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