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Updated: Feb 7, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
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Multiple Myeloma - Current Standards in Surgical Treatment
Michael Kehrer1, Sebastian Koob1, Andreas Kehrer2
1Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Bonn.
Zeitschrift Fur Orthopadie Und Unfallchirurgie
|August 1, 2018
Summary
Surgery is crucial for managing bone damage in multiple myeloma (a blood cancer), helping patients retain function and mobility. Treatment strategies are tailored to individual patient needs and disease extent.
Area of Science:
- Oncology
- Orthopedic Surgery
- Hematology
Background:
- Multiple myeloma is a common blood cancer in elderly patients, leading to osteolytic bone destruction and pathological fractures.
- It is the most frequent spinal tumor, causing significant morbidity, including fractures and neurological deficits in a substantial percentage of patients.
- Surgical intervention is frequently necessary alongside systemic therapy for bone defect reconstruction and stabilization in multiple myeloma.
Purpose of the Study:
- To evaluate the current status of surgical therapy for multiple myeloma.
- To review primary and secondary literature on surgical management of myeloma-related bone complications.
- To outline indications, surgical options, and treatment considerations for multiple myeloma bone lesions.
Main Methods:
- A comprehensive literature search was conducted in PubMed.
- Keywords used included "multiple myeloma" and "surgery" or "fracture".
- Included literature spanned systematic reviews, meta-analyses, clinical studies, and international recommendations from 1975 to spring 2018.
Main Results:
- Stabilizing surgery is essential for restoring function and mobility in myeloma-affected bone sections.
- Indications for surgery are based on lesion extent, fractures, neurological deficits, and intractable pain.
- Surgical options range from hybrid stabilization and prostheses for extremities to minimally invasive procedures (kyphoplasty, vertebroplasty) and spinal reconstruction for spinal involvement.
Conclusions:
- Surgical treatment is vital for reducing distress and preserving function, mobility, and quality of life in multiple myeloma patients.
- The choice of surgical approach and timing depends on the patient's individual risk profile and prognosis.
- Surgical objectives aim for stable, long-term solutions, often followed by radiotherapy.
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