Solid lipid nanocarriers in drug delivery: characterization and design

Area of Science:

• Pharmaceutical Nanotechnology
• Drug Delivery Systems
• Materials Science

Background:

• Solid lipid nanoparticles (SLNCs) are advanced drug carriers with potential for both systemic and local therapeutic applications.
• Efficient delivery of active substances to target sites and improved drug absorption remain significant challenges in nanomedicine.

Purpose of the Study:

• To review and discuss the influence of excipients and preparation methods on SLNC properties.
• To analyze the impact of these factors on drug absorption and efficacy across various administration routes.

Main Methods:

• Literature review and discussion of existing studies on SLNCs.
• Analysis of the relationship between formulation components, fabrication techniques, and nanoparticle characteristics.

Main Results:

• SLNCs exhibit unique properties suitable for parenteral, oral, ocular, pulmonary, and topical delivery.
• Simultaneous consideration of excipients and fabrication methods is crucial for optimizing nanoparticle size, drug absorption, and therapeutic efficacy, particularly for local treatments.

Conclusions:

• SLNCs are attractive for diverse drug delivery applications, enhancing local efficacy while minimizing systemic side effects.
• Further research into SLNC interactions with biological tissues is essential for developing functional nanoparticles for clinical use.