Related Experiment Video

Updated: Feb 7, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
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Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

Published on: October 25, 2011

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Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma

Young Saing Kim1, Kyung Kim2, Ghee-Young Kwon3

  • 1Division of Medical Oncology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.

BMC Urology
|August 2, 2018
PubMed
Abstract

Insights

FGFR3 aberrations were found in 22% of muscle-invasive urothelial carcinoma (UC) patients. FGFR3 mutations and FGFR3-TACC3 fusions identify potential candidates for novel FGFR-targeted therapies.

Area of Science:

  • Oncology
  • Genetics
  • Urology

Background:

  • Fibroblast Growth Factor Receptor 3 (FGFR3) is implicated as a therapeutic target in urothelial carcinoma (UC).
  • Understanding FGFR3 aberration profiles is crucial for developing targeted treatments in UC.

Purpose of the Study:

  • To determine the frequency and types of FGFR3 aberrations in patients with muscle-invasive UC.
  • To assess FGFR3 aberration rates in relation to tumor location (bladder vs. renal pelvis/ureter).

Main Methods:

  • Analysis of surgical tumor samples from 74 patients undergoing radical cystectomy or ureteronephrectomy.
  • Detection of FGFR3 aberrations using Ion AmpliSeq Cancer Hotspot Panel v2 and nCounter Copy Number Variation Assay.

Main Results:

  • FGFR3 alterations were identified in 22% of patients, with mutations being the most common.
  • Specific mutations (e.g., Y373C, N532D) and FGFR3-TACC3 rearrangements were observed.
  • Higher, though not statistically significant, FGFR3 aberration rates were noted in bladder UC compared to UC of the renal pelvis and ureter.

Conclusions:

  • FGFR3 aberrations are present in a significant subset of muscle-invasive UC.
  • Patients with FGFR3 mutations or FGFR3-TACC3 fusions are potential candidates for perioperative FGFR-targeted therapy.
Keywords:
FGFRFusionMutationUrothelial carcinoma

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