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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Immune cell subset differentiation and tissue inflammation.

Pu Fang¹, Xinyuan Li², Jin Dai¹

¹Center for Metabolic Disease Research, Lewis Kats School of Medicine, Temple University, Medical Education and Research Building, Room 1060, 3500 N. Broad Street, Philadelphia, PA, 19140, USA.

Journal of Hematology & Oncology

|August 2, 2018

Summary

This summary is machine-generated.

This review details diverse immune cell subsets and their roles in inflammation, cardiovascular diseases, and cancer. Understanding these specialized cells is key to developing new treatments for complex diseases.

Keywords:

B cell Cancer Cardiovascular disease Dendritic cell Immune cell subset differentiation Macrophage Monocyte T cell

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Area of Science:

Immunology
Molecular Biology
Pathophysiology

Background:

Immune cells were historically viewed as solely pro-inflammatory.
Recent discoveries reveal diverse immune cell subsets with specialized functions.
These subsets regulate both immune activation and suppression in tissues.

Purpose of the Study:

To summarize current knowledge on major immune cell subsets (T cells, B cells, dendritic cells, monocytes, macrophages).
To highlight their molecular characteristics, distribution, and functions in health and disease.
To present a model of inflammatory mononuclear cell differentiation and interaction in tissue inflammation.

Main Methods:

Review of current literature on immune cell subsets.
Analysis of molecular characterization, frequency, and tissue distribution.
Description of cytokine production, signaling, and disease associations.

Main Results:

Detailed characterization of various immune cell subsets in humans and mice.
Elucidation of their roles in cardiovascular diseases and cancers.
Presentation of a model for inflammatory mononuclear cell differentiation and interaction.

Conclusions:

Immune cell subsets are critical regulators of immune responses and tissue homeostasis.
Their complex interactions form a "pathophysiological network" influencing inflammatory diseases and cancers.
This review provides a comprehensive guideline for understanding immune cell differentiation and its disease relevance.