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The PreCancer Atlas (PCA).

Sudhir Srivastava1, Sharmistha Ghosh1, Jacob Kagan1

  • 1Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Cancer
|August 2, 2018
PubMed
Summary

The National Cancer Institute

Area of Science:

  • Oncology
  • Carcinogenesis
  • Molecular Biology

Background:

  • Early cancer detection improves survival rates.
  • Premalignant lesions require better understanding for effective intervention.
  • Current knowledge of early carcinogenesis is limited.

Purpose of the Study:

  • To create a comprehensive map of precancerous lesions using histological and multi-omic data.
  • To characterize the molecular, cellular, and structural evolution of premalignant lesions.
  • To identify mechanisms driving the transition from premalignancy to invasive cancer.

Main Methods:

  • Histological mapping of precancerous lesions.
  • Multi-omic data integration (genomics, transcriptomics, etc.).
  • Spatio-temporal analysis of lesion development.

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Main Results:

  • Detailed molecular and cellular characterization of premalignant lesions.
  • Insights into the evolutionary pathways from precancer to cancer.
  • Identification of previously unknown molecular mechanisms in early carcinogenesis.

Conclusions:

  • The PreCancer Atlas (PCA) will revolutionize understanding of carcinogenesis initiation.
  • PCA data will facilitate development of novel early detection and prevention strategies.
  • Findings may lead to changes in clinical oncology standards of practice.