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Preclinical models for colonic absorption, application to controlled release formulation development.

Isabel Lozoya-Agullo1, Isabel González-Álvarez2, Matilde Merino-Sanjuán3

  • 1Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, Spain; Pharmacokinetics, Pharmaceutical Technology and Parasitology, University of Valencia, Spain.

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This review explores oral controlled release (CR) drug delivery, focusing on colonic absorption. It examines factors influencing CR product performance and formulation strategies for enhanced drug delivery.

Keywords:
ColonColonic permeabilityControlled release formulationsDrug absorptionOral route

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Colonic Drug Absorption

Background:

  • Oral controlled release (CR) formulations offer significant advantages for drug administration.
  • A key feature of CR products is their primary drug absorption in the colon.
  • Understanding colonic drug absorption is crucial for effective CR formulation design.

Purpose of the Study:

  • To review physiological and physicochemical factors impacting orally administered CR products.
  • To discuss various strategies for developing effective CR dosage forms.
  • To analyze methods for evaluating CR formulation efficacy and colonic permeability.

Main Methods:

  • Literature review of physiological and physicochemical factors.
  • Analysis of CR formulation development strategies.
  • Evaluation of methods for assessing formulation efficacy and permeability.

Main Results:

  • Identified key factors affecting CR product performance in the colon.
  • Outlined diverse strategies for designing CR dosage forms targeting colonic release.
  • Discussed various in vitro and in vivo methods for efficacy and permeability evaluation.

Conclusions:

  • Effective CR formulation design requires a thorough understanding of colonic physiology and physicochemical properties.
  • Multiple strategies exist for developing CR products with colonic drug absorption.
  • Appropriate evaluation methods are essential for ensuring the efficacy of CR formulations.