Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymoma immunological and ultrastructural characterization.

M A Pedraza

    Cancer
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    A thymoma, a mediastinal mass, was linked to abnormal T-cells in a patient. Treatment, including tumor removal and radiotherapy, resolved the atypical lymphocytes and normalized immune cell balance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner.

    Journal of acquired immune deficiency syndromes (1999)·1999
    Same author

    Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes.

    Oncogene·1999
    Same author

    CCR5 genotype and HIV-1 infection in perinatally-exposed infants.

    The Journal of infection·1999
    Same author

    Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains.

    European journal of immunology·1998
    Same author

    In vitro selective elimination of HIV-infected cells from peripheral blood in AIDS patients by the immunotoxin DAB389CD4.

    AIDS (London, England)·1998
    Same author

    Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

    The EMBO journal·1995
    Same journal

    Real-world effectiveness of chemotherapy regimens after immunotherapy in patients with advanced melanoma in Spain: Results from the GEM1801 study.

    Cancer·2026
    Same journal

    Bendamustine in indolent lymphoma: Letting the dust settle down.

    Cancer·2026
    Same journal

    Top advances of the year: Bispecific antibodies in early lines of therapy in multiple myeloma.

    Cancer·2026
    Same journal

    Direct oral anticoagulants and warfarin in atrial fibrillation patients with cancer by anticoagulation quality.

    Cancer·2026
    Same journal

    Sexual orientation and gender identity based disparities in colorectal, cervical, and breast cancer screening in the United States.

    Cancer·2026
    Same journal

    Toward exercise as standard care for older cancer survivors.

    Cancer·2026
    See all related articles

    Area of Science:

    • Immunology
    • Oncology
    • Pathology

    Background:

    • Mediastinal masses can present with complex hematological manifestations.
    • Thymoma, a tumor of the thymus, is associated with various paraneoplastic syndromes.
    • Understanding the immunological impact of thymoma is crucial for diagnosis and treatment.

    Observation:

    • A 69-year-old male presented with a mediastinal mass and atypical lymphoid cells in peripheral blood and bone marrow.
    • Microscopic examination confirmed the mediastinal mass as a thymoma.
    • Both the tumor and peripheral blood exhibited T-cell differentiation and phytohemagglutinin (PHA) responsiveness.

    Findings:

    • The atypical lymphocytes in circulation were identified as T-cells.
    • Surgical excision of the thymoma followed by radiotherapy led to the disappearance of atypical lymphocytes.

    Related Experiment Videos

  • Post-treatment, the patient's peripheral blood B/T cell ratio and PHA responsiveness normalized.

    • Implications:

    • This case highlights the potential for thymoma to induce significant T-cell abnormalities.
    • Successful treatment of the thymoma resulted in the resolution of these hematological findings.
    • It underscores the importance of investigating mediastinal masses in patients with unexplained lymphoid cell anomalies.