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Updated: Feb 7, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Synthesis and antimicrobial activities of novel sorbic and benzoic acid amide derivatives
Qingyi Wei1, Xiaomei Wang1, Jun-Hu Cheng1
1School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, PR China; Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China; Engineering and Technological Research Centre of Guangdong Province on Intelligent Sensing and Process Control of Cold Chain Foods, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China.
Abstract:
A series of sorbic and benzoic acid amide derivatives were synthesized by conjugating sorbic acid (SAAD, a1-a7) or benzoic acid (BAAD b1-b6) with amino acid esters and their antimicrobial activities were investigated against Escherichia coli, Bacillus subtilis and Staphylococcus aureus, mixed bacteria from rancid milk, Saccharomyces cerevisiae, and Aspergillus niger. The antimicrobial activity of sorbic acid amides was better than that of benzoic acid amides. The minimum inhibitory concentrations (MIC) of compound isopropyl N-[1-oxo-2, 4-hexadien-1-yl]-L-phenylalaninate (a7) were 0.17 mM against B. subtilis, and 0.50 mM against S. aureus, while the MIC values of sorbic acid were more than 2 mM respectively. Also, compound a7 displayed pH-independent antimicrobial activity in the range of pH 5.0-9.0 and was effective at pH 9.0. These results demonstrated that the conjugation of sorbic acid with amino acid esters led to significant improvement of in vitro antimicrobial attributes, but little effect was observed for benzoic acid amide derivatives.
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