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Updated: Feb 7, 2026
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Men present with higher clinical class of chronic venous disease before endovenous catheter ablation
Yasaman Kavousi1, Ziad Al Adas1, Efstathios Karamanos1
1Division of Vascular Surgery, Henry Ford Health System, Detroit, Mich.
Insights
Older age and male sex are significant risk factors for advanced chronic venous disease (CVD) requiring vein ablation. Men are more likely to present with severe CVD despite higher varicose vein incidence in women.
Area of Science:
- Vascular Surgery
- Phlebology
- Epidemiology
Background:
- Chronic venous disease (CVD) risk factors are known, but predisposing factors for advanced stages are not well-established.
- Understanding these factors is crucial for targeted patient management and treatment strategies.
Purpose of the Study:
- To identify demographic and risk factors associated with advanced clinical presentation of CVD in patients undergoing vein ablation.
- To compare risk factors between mild-moderate (C1-C3) and severe (C4-C6) CVD groups.
Main Methods:
- Retrospective analysis of the Vascular Quality Initiative Varicose Vein Registry (2015-2016).
- Inclusion of patients undergoing endovenous laser treatment or radiofrequency ablation.
- Comparison of demographics and comorbidities between mild-moderate and severe CVD groups using univariate and multivariate analysis.
Main Results:
- Male sex (OR, 2.6; P < .001) and older age (average 63 vs 56 years) were significantly associated with severe CVD.
- Severe CVD accounted for 21% of the 650 treated truncal veins.
- Race, diabetes, BMI, pregnancies, CHF, VTE history, anticoagulation, and smoking status did not impact CVD severity.
Conclusions:
- Older age and male sex are independent risk factors for advanced CVD requiring vein ablation.
- Men are more prone to severe CVD presentation for truncal vein ablation, contrasting with higher overall varicose vein prevalence in women.
Background:
Risk factors for chronic venous disease (CVD) have been widely reported in population health management. However, predisposing factors associated with patients treated for advanced stages of CVD have yet to be established. We examined the demographics and risk factors associated with advanced clinical presentation of CVD for patients referred for vein ablation.
Methods:
Retrospective analysis of our institutional Vascular Quality Initiative Varicose Vein Registry included endovenous laser treatment and radiofrequency ablation procedures at our tertiary institution, community hospital, and outpatient vein clinic between January 2015 and December 2016. All incompetent truncal veins were divided into two groups based on the Clinical, Etiology, Anatomy, and Pathophysiology clinical class of CVD: mild-moderate (C1-C3) and severe (C4-C6). The two groups were compared in terms of their demographics and medical comorbidities using univariate and multivariate analysis. Data analysis was conducted on SPSS 22.0 (IBM Corp, Armonk, NY).
Results:
During the study period, a total of 650 incompetent truncal veins were ablated. The mean age of patients was 58 years, and 73% were female. Severe CVD composed 21% of the cohort. Male sex was a risk for advanced CVD (odds ratio, 2.6; P < .001). Older age was also associated with severe CVD; the average age was 63 years for patients with advanced stage CVD vs 56 years for mild to moderate CVD (P < .001). Race, diabetes, body mass index, number of pregnancies, congestive heart failure, history of venous thromboembolism, current anticoagulation, and history of smoking or current smoking status did not affect the severity of CVD.
Conclusions:
Among patients treated with vein ablation for superficial venous insufficiency, older age and male sex were associated with increased severity of advanced CVD. Despite the higher incidence of varicose veins among women, men are more likely to have clinically advanced CVD when they present for truncal vein ablation.
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