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Do Fungi Undergo Apoptosis-Like Programmed Cell Death?

J Marie Hardwick1

  • 1Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA hardwick@jhu.edu.

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|August 2, 2018
PubMed
Summary

Fungi may not undergo apoptosis, but research suggests they might possess self-destructive processes. Further investigation into fungal programmed cell death mechanisms is warranted.

Keywords:
MLKLapoptosiscell deathcell-autonomousfungimycoptosisnecroptosispathogenic fungiprogrammed cell deathyeast

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Area of Science:

  • Mycology
  • Cell Biology
  • Biochemistry

Background:

  • The application of animal-centric cell death terminology to fungi is debated.
  • Definitions of apoptosis and programmed cell death are crucial for understanding fungal cell demise.

Purpose of the Study:

  • To clarify whether fungi exhibit apoptosis-like programmed cell death.
  • To explore the existence of self-injurious mechanisms in fungi.

Main Methods:

  • Comparative analysis of cell death definitions.
  • Review of existing literature on fungal cell death.

Main Results:

  • The term "apoptosis" is difficult to apply directly to fungi.
  • Evidence suggests fungi may have evolved distinct self-destructive processes.

Conclusions:

  • Fungal apoptosis is questionable based on current definitions.
  • Further research is needed to identify programmed or extemporaneous self-destruction in fungi.