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Novel bone wax based on tricalcium silicate cement and BGs mixtures
Weijing Cao1, Yangyang Peng2, Yin Zhang1,3
1College of Materials Science and Engineering, Nanjing Tech University, Nanjing 210009, People's Republic of China.
None:
Classic bone wax is effectively hemostatic and low-cost, but it has shortcomings like infection and nonabsorbability. A novel self-curing bone wax was developed by mixing tricalcium silicate (C3S) cement and 58S bioactive glass/chitosan/carboxy methyl cellulose (BG/CS/CMC, referred to as BGs) to overcome these problems. It was found that the addition of BGs improved anti-washout and operational properties of C3S, and C3S had good self-curing and mechanical behavior. C3S/BGs with a mass ratio of 2:1 possessed better material performance in the setting time, mechanical strength, and injection property in the test group. X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and scanning electron microscopy (SEM) confirmed the hydroxyapatite (HAp) formation ability of C3S/BGs. The cell compatibility was investigated in vitro by culturing mouse embryonic osteoblast precursor cells (MC3T3-E1) in the extract of C3S/BGs. The results showed that the bone wax compound presented low cytotoxicity and good cell proliferation.
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