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Therapy of Mucormycosis

Nikolaos V Sipsas1, Maria N Gamaletsou2, Amalia Anastasopoulou3

  • 1Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 115 27 Athens, Greece. nsipsas@med.uoa.gr.

Journal of Fungi (Basel, Switzerland)
|August 2, 2018
PubMed

Insights

Management of mucormycosis remains challenging due to limited clinical trial data. Individualized treatment plans are crucial, considering host factors and antifungal properties for this opportunistic infection.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • Mucormycosis is a rare, severe opportunistic infection caused by Mucorales fungi.
  • Current antifungal agents include amphotericin B, posaconazole, and isavuconazole.
  • Lack of prospective randomized clinical trials complicates treatment guidelines.

Purpose of the Study:

  • To review the current treatment options for mucormycosis.
  • To highlight the uncertainties in managing this infection.
  • To emphasize the need for individualized therapeutic strategies.

Main Methods:

  • Mini-review of existing literature on mucormycosis treatment.
  • Analysis of current antifungal agents and their properties.
  • Consideration of host-related factors in disease management.

Main Results:

  • Despite new agents, significant uncertainties persist in mucormycosis therapy.
  • Disease heterogeneity (host, site, pathogen) necessitates tailored approaches.
  • No definitive guidelines exist due to a lack of clinical trial evidence.

Conclusions:

  • Individualized mucormycosis management plans are essential.
  • Factors to consider include host immunosuppression, comorbidities, diagnostic certainty, infection site, and antifungal drug characteristics.
  • Further research, including randomized trials, is needed to establish evidence-based treatment protocols.
Keywords:
amphotericin Bisavuconazoleleukemiamucormycosisposaconazolestem cell transplantationsurgerytreatment

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