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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Feb 7, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Landmarks in prostate cancer.

Niranjan J Sathianathen1,2,3, Badrinath R Konety4, Juanita Crook5

  • 1Department of Urology, University of Minnesota, Minneapolis, MN, USA. niranjan19@gmail.com.

Nature Reviews. Urology
|August 2, 2018
PubMed
Summary
This summary is machine-generated.

Extensive prostate cancer research has advanced disease understanding and management. Key developments include improved diagnostics, nerve-sparing surgery, active surveillance, and systemic therapies, enhancing patient outcomes.

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Area of Science:

  • Oncology
  • Urology
  • Medical Research

Background:

  • Prostate cancer research has significantly evolved, impacting clinical practice and guidelines.
  • Understanding of the disease's epidemiology, natural history, and detection has grown substantially.
  • Past research has laid the groundwork for current and future advancements in prostate cancer care.

Purpose of the Study:

  • To review the significant discoveries and advancements in prostate cancer research.
  • To highlight how these advancements have reshaped the diagnosis and management of prostate cancer.
  • To underscore the impact of research on clinical practice and treatment guidelines.

Main Methods:

  • Review of key research findings and their translation into clinical practice.
  • Analysis of historical developments in prostate cancer detection, grading, and staging.
  • Examination of therapeutic innovations, including surgical techniques and systemic treatments.

Main Results:

  • Development of the Gleason score for accurate prognosis prediction.
  • Advancement of nerve-sparing surgery for radical prostatectomy.
  • Implementation of active surveillance for low-risk disease and improved outcomes with chemotherapy/hormonal therapy for advanced disease.

Conclusions:

  • Research has profoundly changed prostate cancer management, from diagnosis to treatment.
  • Innovations like the Gleason score and active surveillance have improved patient care and outcomes.
  • Continued research and clinical trials are anticipated to bring further practice-changing results.