Related Experiment Video
Updated: Feb 7, 2026

Robotic Ablation of Atrial Fibrillation
Published on: May 29, 2015
Non-Gated Triple Flash Coronary Computed Tomographic Angiography in Patients with Atrial Fibrillation
Rami M Abazid1, Osama A Smettei1, Akram F Eldesoky1
1Prince Sultan Cardiac Center Qassim (PSCCQ), King Fahad Specialist Hospital.
Insights
Non-gated triple Flash (NGTF) coronary computed tomography angiography (CTA) offers similar image quality to retrospectively gated helical (RGH) scans in atrial fibrillation (AF) patients, with substantially lower radiation exposure.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Medical Technology
Background:
- Atrial fibrillation (AF) poses challenges for coronary computed tomography angiography (CTA) image acquisition.
- Current CTA protocols for AF patients are not optimized.
- Development of a single-heartbeat CTA protocol for AF is needed.
Purpose of the Study:
- To design and evaluate a single-heartbeat coronary CTA protocol for patients with atrial fibrillation.
- To compare image quality and radiation dose between non-gated triple Flash (NGTF) and retrospectively gated helical (RGH) CTA scan modes.
Main Methods:
- 32 AF patients with low coronary artery disease probability underwent CTA using a 256-slice scanner.
- Twelve patients received NGTF CTA, and 20 patients received RGH CTA.
- Coronary artery image quality was assessed using a 4-point scale; radiation dose was recorded.
Main Results:
- No significant difference in image quality scores between NGTF and RGH scans (2.8 ± 0.8 vs. 2.9 ± 0.6).
- Similar rates of coronary arteries with extensive blurring across both protocols (8.3% NGTF vs. 6.6% RGH).
- Significantly lower radiation dose with NGTF (382 ± 35 mGy) compared to RGH (835 ± 146 mGy).
Conclusions:
- Single-heartbeat NGTF CTA provides comparable image quality to RGH CTA in AF patients.
- NGTF CTA significantly reduces radiation exposure in AF patients.
- Further research is needed to assess NGTF protocol applicability in next-generation CT scanners.
Background:
Atrial fibrillation (AF) presents a potential challenge when performing coronary computed tomography angiography (CTA). To date, there is no ideal protocol for CTA in patients with AF. We sought to design a protocol for single-heartbeat coronary CTA in patients with AF.
Methods:
We enrolled 32 patients with AF and a very low probability of coronary artery disease who were referred for CTA to assess pulmonary vein anatomy for catheter ablation. A 256-slice scanner was used. Twelve patients underwent CTA using non-gated triple Flash (NGTF) consisting of three prospective electrocardiogram (ECG)-triggered helical scans with a built-in ECG simulator, while retrospectively gated helical (RGH) was used in 20 patients. Radiation dose, and a 4-point scale was used to assess coronary artery image quality between CTA scan modes.
Results:
A total of 96 vessels were analyzed. The 4-point score showed no significant differences between the RGH and NGTF scans (2.9 ± 0.6 vs. 2.8 ± 0.8, respectively; p = 0.34). The number of coronary arteries with extensive blurring did not significantly differ between the protocols, and included four vessels (6.6%) in RGH vs. three vessels (8.3%) in NGTF (p = 0.5). Radiation exposure was significantly higher with RGH scans, with a dose-length product of 835 ± 146 mGy compared with 382 ± 35 mGy for NGTF (p < 0.0001).
Conclusions:
Single heartbeat NGTF CTA has comparable image quality and significantly lower radiation dose compared to RGH scans in patients with AF. Whether this protocol can be used in next-generation computed tomography scanners has yet to be determined.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid Fibrils
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Underflow Gates
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Scalar and Vector Triple Products
The scalar triple product is the dot product of a vector with the cross product of two vectors....

