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Related Experiment Video

Updated: Feb 7, 2026

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis
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Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

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Olmutinib Induced Lichen Planus Like Eruption.

Seung Hwan Oh1, Hyun Jeong Byun1, Se Jin Oh1

  • 1Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Annals of Dermatology
|August 2, 2018
PubMed
Summary

A rare skin reaction, drug-induced lichen planus-like eruption, occurred in a patient treated with olmutinib, a cancer drug. Treatment involved corticosteroids and a reduced olmutinib dose, leading to lesion improvement.

Keywords:
Drug eruptionsEGFR tyrosine kinase inhibitorLichen planusOlmutinib

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Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Drug-induced lichen planus-like eruption is an uncommon adverse cutaneous reaction.
  • This eruption presents as symmetric, erythematous or violaceous plaques resembling lichen planus.

Observation:

  • A 50-year-old male developed scaly, violaceous plaques and dusky brown macules after four months of olmutinib treatment.
  • Olmutinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor approved for non-small cell lung cancer.

Findings:

  • Biopsy confirmed lichen planus features, leading to a diagnosis of olmutinib-induced lichen planus-like eruption.
  • Treatment included oral methylprednisolone, topical desoxymethasone, and a dose reduction of olmutinib.

Implications:

  • This case highlights a rare side effect of olmutinib, emphasizing the importance of monitoring for cutaneous reactions.
  • Successful management involved a combination of topical/systemic corticosteroids and dose adjustment of the offending drug.