Salinity adaptation in fish: interaction of thyroxine with fish gill mitochondria

When the freshwater fish Sarotherodon mossambicus is exposed to an ionoosmotic stress, extensive changes take place in the energetics of the gill mitochondria. These changes are reversed when thyroxine is administered to the fish prior to exposure to stress [K. Shivakumar and J. Jayaraman (1984) Arch. Biochem. Biophys. 233, 728]. The presence of a thyroxine binding component in the mitochondrial inner membrane, its characteristics, and its possible involvement in the salinity adaptation process are discussed.