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Related Experiment Videos

Antioxidant action of antimalarials.

Y Miyachi, A Yoshioka, S Imamura

    Annals of the Rheumatic Diseases
    |March 1, 1986
    PubMed
    Summary

    Antimalarial drugs like chloroquine and quinacrine inhibit reactive oxygen species production. This antioxidant action may protect against inflammation and tissue damage.

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    Area of Science:

    • Biochemistry
    • Pharmacology
    • Immunology

    Background:

    • Reactive oxygen species (ROS) play a role in inflammation and tissue damage.
    • Antimalarial drugs are used to treat malaria but may have other biological activities.

    Purpose of the Study:

    • To investigate the effects of antimalarials (chloroquine, quinacrine) on ROS generation.
    • To explore the potential antioxidant and anti-inflammatory properties of these drugs.

    Main Methods:

    • Experiments were conducted using polymorphonuclear leucocytes (white blood cells).
    • The xanthine-xanthine oxidase system was used as a model for ROS production.
    • Effects on cell functions, including membrane phospholipid methylation, were assessed.

    Main Results:

    • Antimalarials demonstrated inhibitory effects on ROS production in both systems.
    • The mechanism may involve interference with cell functions like membrane phospholipid methylation.

    Conclusions:

    • Antimalarial agents possess antioxidant properties.
    • They may protect against auto-oxidative tissue damage at inflammatory sites, conferring anti-inflammatory effects.

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