Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Power in a Three-Phase Circuit

Power in a Three-Phase Circuit

Three-phase systems have two configurations: the wye and delta. A star configuration can be three or four wires; in a delta configuration, the components are connected in a closed loop. Instantaneous power refers to the power value at a precise moment, and in a balanced three-phase system, it is constant. This is because the sum of the instantaneous powers in the three phases remains steady over time, despite individual fluctuations, due to the symmetry and phase relationship. The total...

Power Distribution in Three-phase and Single Phase Circuits

Power Distribution in Three-phase and Single Phase Circuits

Power distribution within electrical circuits is a foundational aspect of residential and industrial energy systems. While single-phase power is common in residential settings, three-phase power is the standard for industrial environments with heavy machinery. Each system is different and has advantages, and it's crucial to understand the underlying principles of power distribution and material efficiency.
Single-Phase Power Distribution:
Single-phase circuits are typical in household settings;...

Power System Three-Phase Short Circuits

Power System Three-Phase Short Circuits

Determining the subtransient fault current in a power system involves representing transformers by their leakage reactances, transmission lines by their equivalent series reactances, and synchronous machines as constant voltage sources behind their subtransient reactances. In this analysis, certain elements are excluded, such as winding resistances, series resistances, shunt admittances, delta-Y phase shifts, armature resistance, saturation, saliency, non-rotating impedance loads, and small...

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...

Prediction Intervals

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.

Uniform Distribution

Uniform Distribution

The uniform distribution is a continuous probability distribution of events with an equal probability of occurrence. This distribution is rectangular.
Two essential properties of this distribution are

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Minimum noninferiority dose for phase I clinical trials with immunotherapy.

Biometrics·2026

Same author

Phase I design for partially ordered groups with late-onset toxicity.

Clinical trials (London, England)·2026

Same author

Two-Stage Double-Arm Trial Optimal Design of Restricted Mean Survival Time With Sculpted Critical Region.

Statistics in medicine·2026

Same author

BAR12: Bayesian Autoregressive Phase 1-2 Design for Cell Therapy Trials With Manufacturing Changes.

Statistics in medicine·2026

Same author

Generalized Pairwise Comparisons in Dose Optimization Oncology Trials: Beyond Safety to Multi-outcome Dose Selection.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

Patient Retreat in Dose Escalation for Phase I Clinical Trials With Rare Diseases.

Statistics in medicine·2026

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

Uniformly most powerful Bayesian interval design for phase I dose-finding trials.

Ruitao Lin^1,2, Guosheng Yin³

¹Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Pharmaceutical Statistics

|August 2, 2018

Summary

The new uniformly most powerful Bayesian interval (UMPBI) design improves phase I clinical trials by ensuring dose levels converge to the optimal maximum tolerated dose. This method enhances accuracy and minimizes incorrect decisions in dose-finding studies.

Keywords:

Bayes factor dose finding interval design maximum tolerated dose uniformly most powerful Bayesian test

More Related Videos

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

Published on: July 22, 2014

A Two-interval Forced-choice Task for Multisensory Comparisons

A Two-interval Forced-choice Task for Multisensory Comparisons

Published on: November 9, 2018

Related Experiment Videos

Last Updated: Feb 7, 2026

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

Published on: July 22, 2014

A Two-interval Forced-choice Task for Multisensory Comparisons

A Two-interval Forced-choice Task for Multisensory Comparisons

Published on: November 9, 2018

Area of Science:

Clinical Trials
Biostatistics
Pharmacology

Background:

Interval designs are popular for phase I clinical trials due to simplicity.
Existing interval designs often fail to converge to optimal dose levels.
Dose-finding requires precise identification of the maximum tolerated dose (MTD).

Purpose of the Study:

To develop a novel interval design for phase I clinical trials.
To address the convergence limitations of current interval designs.
To introduce a design with improved optimality and accuracy in dose selection.

Main Methods:

Development of the uniformly most powerful Bayesian interval (UMPBI) design.
Utilizing the rejection region of the uniformly most powerful Bayesian test (UMPBT).
Simulation studies to compare UMPBI with existing interval designs.

Main Results:

The UMPBI design demonstrates convergence properties, shrinking intervals to the toxicity target.
Recommended doses from UMPBI converge to the true MTD as sample size increases.
UMPBI minimizes the probability of incorrect decisions, showing competitive performance.

Conclusions:

The UMPBI design offers enhanced convergence and optimality for phase I dose-finding.
This new design provides a more accurate and reliable approach to MTD identification.
UMPBI shows promise for application in complex clinical trial settings, such as combination therapy trials.