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Updated: Feb 7, 2026
Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
Combination of virtual point detector concept and fluence compensation in acoustic resolution photoacoustic
Valeriya V Perekatova1, Mikhail Yu Kirillin1, Ilya V Turchin1
1Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia.
Abstract:
We propose a hybrid approach to image enhancement in acoustic resolution photoacoustic microscopy. The developed technique is based on compensation for nonuniform spatial sensitivity of the optoacoustic (OA) system in both optical and acoustic domains. Spatial distribution of optical fluence is derived from full three-dimensional Monte Carlo simulations accounting for conical geometry of tissue laser illumination at the wavelength of 532 nm. Approximate nonuniform spatial response of acoustic detector with numerical aperture of 0.6 is derived from the two-dimensional k-Wave modeling. Application of the developed technique allows to improve the spatial resolution and to balance in-depth signal-level distribution in OA images of phantom and in-vivo objects.
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