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Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
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Paraneoplastic Sweet's syndrome.

Daniela Gomes Cunha1, Gabriella Campos-do-Carmo1, Julia Macchione Marujo1

  • 1Oncological Dermatology Service, Instituto Nacional do Câncer, Rio de Janeiro (RJ), Brazil.

Anais Brasileiros De Dermatologia
|August 2, 2018
PubMed
Summary
This summary is machine-generated.

Sweet's syndrome is a rare skin condition with unknown causes, often linked to other diseases. This case highlights a rare instance of paraneoplastic Sweet's syndrome associated with cervical cancer.

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Sweet's syndrome is a rare neutrophilic dermatosis.
  • Its pathogenesis remains largely unknown.
  • It is associated with infections, autoimmune diseases, inflammatory bowel diseases, vaccination, medications, and neoplasms.

Observation:

  • Hematologic malignancies are most commonly linked to paraneoplastic Sweet's syndrome.
  • Solid tumors, including genitourinary tract tumors, can occasionally present with this condition.
  • A rare case of paraneoplastic Sweet's syndrome in the context of cervical cancer is presented.

Findings:

  • This report details a rare association between cervical cancer and paraneoplastic Sweet's syndrome.
  • It underscores the potential for Sweet's syndrome to manifest as a paraneoplastic phenomenon in gynecologic malignancies.

Implications:

  • This case expands the understanding of paraneoplastic syndromes related to solid tumors.
  • It suggests that Sweet's syndrome should be considered in the differential diagnosis of patients with cervical cancer presenting with characteristic skin lesions.
  • Further research is warranted to elucidate the mechanisms underlying this association.