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Updated: Feb 7, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Development of C2-Symmetric Chiral Bifunctional Triamines: Synthesis and Application in Asymmetric Organocatalysis
Santiago Cañellas1,2, Pedro Alonso1, Miquel À Pericàs1,3
1Institute of Chemical Research of Catalonia (ICIQ) , The Barcelona Institute of Science and Technology , Avda. Països Catalans 16 , E-43007 Tarragona , Spain.
Abstract:
The synthesis and application of a newly designed C2-symmetric chiral bifunctional triamine family ( C2-CBT) is reported. These enantiopure chiral triamine scaffolds can be accessed in multigram amounts from simple amino acids while avoiding chromatographic purification. As a proof of principle, C2-CBT has been studied in the aldol reaction of cyclic ketones with isatins, with the target tertiary alcohols being formed in a highly efficient manner. Catalyst recovery by simple extraction techniques and subsequent reuse has been performed.
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