Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyrotropin receptor antibodies.

B Rees Smith, F M Creagh, F A Hashim

    Arzneimittel-Forschung
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Autoimmune polyendocrine syndrome type 1: an Italian survey on 158 patients.

    Journal of endocrinological investigation·2021
    Same author

    Practical applications of studies on the TSH receptor and TSH receptor autoantibodies.

    Endocrine·2020
    Same author

    Mechanisms of Action of TSHR Autoantibodies.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2015
    Same author

    Estimation of regional cerebral blood flow using N-isopropyl-p-123I iodoamphetamine acquisition data from the lungs and brain. An improved non-invasive technique.

    Nuklearmedizin. Nuclear medicine·2014
    Same author

    Gonadal function in males with autoimmune Addison's disease and autoantibodies to steroidogenic enzymes.

    Clinical and experimental immunology·2014
    Same author

    The dynamic changes of zinc transporter 8 autoantibodies in Czech children from the onset of Type 1 diabetes mellitus.

    Diabetic medicine : a journal of the British Diabetic Association·2013

    Autoantibodies to the thyrotropin (TSH) receptor in Graves' disease typically mimic TSH, causing hyperthyroidism. However, some TSH receptor autoantibodies act as antagonists, binding to the same site but blocking TSH action.

    Area of Science:

    • Endocrinology
    • Immunology
    • Molecular Biology

    Background:

    • The thyrotropin (TSH) receptor is a key transmembrane protein composed of two subunits.
    • The A subunit binds TSH, while the B subunit interacts with adenylate cyclase.
    • Autoantibodies against the TSH receptor are implicated in Graves' disease pathogenesis.

    Purpose of the Study:

    • To investigate the binding characteristics and functional effects of autoantibodies to the TSH receptor.
    • To understand the mechanism by which TSH receptor autoantibodies cause or antagonize TSH action.

    Main Methods:

    • Isoelectric focusing
    • Binding studies
    • Functional assays to determine agonist/antagonist activity

    Related Experiment Videos

    Main Results:

    • TSH receptor autoantibodies bind to the A subunit of the TSH receptor.
    • Most antibodies act as TSH agonists, leading to hyperthyroidism.
    • A subset of antibodies function as TSH antagonists, despite binding to the same receptor region.

    Conclusions:

    • TSH receptor autoantibodies play a central role in Graves' disease.
    • The functional outcome (agonist vs. antagonist) depends on the specific antibody interaction with the TSH receptor's A subunit.