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Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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Regulatory T cells in paracoccidioidomycosis
Vera L G Calich1, Ronei L Mamoni2,3, Flávio V Loures1,4
1Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP) , São Paulo , Brazil.
Virulence
|August 2, 2018
Summary
Regulatory T cells (Tregs) play a dual role in fungal infections caused by Paracoccidioides brasiliensis. While Tregs can limit damaging inflammation, they may also suppress crucial anti-fungal immunity.
Area of Science:
- Immunology
- Mycology
Background:
- Regulatory T cells (Tregs) are critical for immune homeostasis and preventing autoimmunity.
- Paracoccidioides brasiliensis is a significant fungal pathogen causing paracoccidioidomycosis (PCM).
Purpose of the Study:
- To review the role of Tregs in the host response to P. brasiliensis.
- To explore the mechanisms influencing Treg function in PCM.
Main Methods:
- Review of existing literature on Tregs and P. brasiliensis infection.
- Discussion of immune components like TLRs, Dectin-1, NLRP3, MyD88, and IDO in Treg modulation.
- Analysis of Treg influence in a murine model of pulmonary paracoccidioidomycosis.
Main Results:
- Tregs exhibit a dual role in PCM, potentially controlling immunopathology but also impairing antifungal responses.
- Specific immune receptors and enzymes differentially regulate Treg expansion and activity.
- Treg-mediated suppression can inhibit the necessary immunity to control fungal growth.
Conclusions:
- Treg cells significantly impact the outcome of P. brasiliensis infections.
- Understanding Treg dynamics is crucial for developing effective immunotherapies for PCM.
- Targeting Treg function may offer a strategy to balance host defense and tissue protection.
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