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Updated: Feb 7, 2026

Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
Published on: February 7, 2022
A Combination of Furfuryl Cation Induced Three-Component Reactions and Photocatalyst-Free Photoisomerization To
Hengtuo Yang1, Jiawei Guo1, Ziwei Gao1
1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry & Chemical Engineering, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical , Shaanxi Normal University , Xi'an 710062 , China.
Abstract:
A novel stereospecific synthesis of ( Z)- and ( E)-β-triazole-acrylates by the combined use of a multicomponent reaction and photocatalyst-free photoisomerization is presented. The former can be regarded as a furfuryl cation induced formal [3 + 2]-cycloaddition/ring-opening/esterification domino sequence, which provides fast access to a variety of structurally diverse ( Z)-β-triazole-acrylates. The products were further photoisomerized to ( E)-configuration by UV irradiation. This efficient strategy was utilized in the concise synthesis of histone deacetylase inhibtor NSC746457 in high yield.
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