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Direct-acting antiviral treatment of acute hepatitis C virus infections

Suresh Misra1, Douglas T Dieterich1, Behnam Saberi1

  • 1a Division of Liver Diseases, Department of Medicine , Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Expert Review of Anti-Infective Therapy
|August 2, 2018
PubMed

Insights

Treating acute hepatitis C virus (AHCV) infection promptly can prevent chronic disease and transmission. Current research is advancing treatment strategies for at-risk populations.

Area of Science:

  • Hepatology and Infectious Diseases

Background:

  • Hepatitis C causes significant global morbidity and mortality.
  • Acute hepatitis C virus (AHCV) infection is defined as documented infection within six months of exposure.
  • Effective treatment of AHCV can prevent chronic disease and reduce transmission.

Purpose of the Study:

  • To review the epidemiology and natural history of AHCV.
  • To discuss considerations for AHCV treatment decisions.
  • To present current direct-acting antiviral (DAA) therapy guidelines for AHCV.

Main Methods:

  • Literature review of PubMed using relevant keywords.
  • Evaluation of bibliographies for pertinent articles.

Main Results:

  • AHCV treatment offers significant benefits, including disease elimination and prevention of chronic complications.
  • Clinical management is challenged by the identification of asymptomatic cases and lack of comprehensive guidelines.
  • Ongoing research focuses on specific DAA regimens, shorter treatment durations, and targeted screening strategies.

Conclusions:

  • Early treatment of AHCV is crucial for individual patient outcomes and public health.
  • Advancements in DAA therapy and targeted screening are improving clinical management.
  • Further research is needed to optimize identification and treatment of AHCV in at-risk populations.
Abstract

Keywords:
Acute hepatitis C virusHIVdirect-acting antiviral therapysofosbuvir

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