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Updated: Jul 30, 2026

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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Full-face augmentation using Tissuefill mixed with platelet-rich plasma: "Q.O.Fill"
Hyejeong Lee1, Kichan Yoon2, Munjae Lee3
1a The hills Aesthetic Surgical Clinic , Seoul , Korea.
Summary
Q.O.Fill, a new hyaluronic acid filler combined with platelet-rich plasma (PRP), shows excellent facial augmentation results. This safe and effective treatment offers significant aesthetic improvement with minimal complications.
Area of Science:
- Aesthetic Medicine
- Dermatology
- Regenerative Medicine
Background:
- Hyaluronic acid fillers are widely used for soft tissue augmentation.
- Q.O.Fill is a novel filler combining Tissuefill (hyaluronic acid derivatives) with platelet-rich plasma (PRP).
Purpose of the Study:
- To describe the Q.O.Fill injection technique.
- To evaluate the efficacy and safety of Q.O.Fill for facial augmentation.
Main Methods:
- Retrospective chart review over two years.
- Seventy-five Asian participants (mean age 43.5 years) received Q.O.Fill injections.
- Evaluation based on photographic analysis and patient satisfaction.
Main Results:
- 100% of participants showed improvement at six months post-injection.
- 97.3% maintained improvement at six months; 90.7% reported feeling better up to two years.
- Low incidence of adverse events observed.
Conclusions:
- Q.O.Fill injections yield significant aesthetic outcomes.
- The combination of Tissuefill and PRP is a safe and effective facial augmentation method.
- Minimal adverse events reported, suggesting a favorable safety profile.

