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Modulation of dynamin function by small molecules.

Susanne Eschenburg1, Thomas F Reubold1

  • 1Medizinische Hochschule Hannover, Institut für Biophysikalische Chemie, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

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|August 2, 2018
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Summary

Dynamins are crucial for cell membrane remodeling in processes like endocytosis and viral entry. This review overviews small molecules that modulate dynamin function for research and therapeutic potential.

Keywords:
GTPase activitydynaminendocytosisinhibitorsmall molecules

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Dynamins are essential GTPase enzymes critical for membrane remodeling.
  • They play key roles in cellular processes including endocytosis, synaptic vesicle recycling, and spermatogenesis.
  • Dynamin's involvement extends to viral entry and cancer cell motility, highlighting its broad biological significance.

Purpose of the Study:

  • To provide a comprehensive overview of small molecules that modulate dynamin function.
  • To discuss various compound classes currently used to study dynamin.
  • To explore the potential of these small molecules as research tools and future therapeutics.

Main Methods:

  • Literature review of scientific publications on dynamin modulators.
  • Analysis of compound classes affecting dynamin activity.
  • Synthesis of information on mechanisms of action and applications.

Main Results:

  • Identification and categorization of diverse small molecule classes targeting dynamin.
  • Description of how these compounds interfere with or enhance dynamin's membrane remodeling functions.
  • Highlighting the utility of these molecules in dissecting biological mechanisms.

Conclusions:

  • Small molecules offer valuable tools for investigating dynamin-mediated cellular processes.
  • Modulators of dynamin function hold promise for therapeutic applications in various diseases.
  • Further research into dynamin small molecules can unlock new biological insights and treatment strategies.