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Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Endoscopic Studies II: Thoracocentesis01:26

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Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
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Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

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An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
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Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Endoscopic Procedures V: ERCP01:26

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
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Endoscopic techniques for treating gastroesophageal reflux.

Juan Reyes Genere1, Kenneth K Wang

  • 1Mayo Clinic, Rochester, Minnesota, USA.

Current Opinion in Gastroenterology
|August 2, 2018
PubMed
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Endoscopic antireflux therapy offers a minimally invasive option for patients with refractory gastroesophageal reflux disease (GERD). Recent studies show durable symptom improvement and a favorable safety profile, making it a viable treatment consideration.

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Area of Science:

  • Gastroenterology
  • Minimally Invasive Surgery

Background:

  • Medically refractory gastroesophageal reflux disease (GERD) affects many patients seeking non-surgical treatment options.
  • Endoscopic therapy has re-emerged as a minimally invasive antireflux treatment, with improved efficacy and safety.
  • Advances in technology and extensive experience over two decades have led to favorable outcomes.

Purpose of the Study:

  • To review current endoscopic antireflux devices available on the market.
  • To summarize recent studies on endoscopic antireflux therapies, including new devices and long-term data.
  • To discuss the safety and efficacy of endoscopic treatments for GERD.

Main Methods:

  • Review of current literature on endoscopic antireflux devices and therapies.
  • Analysis of short-term and long-term outcome data from clinical studies.
  • Evaluation of safety profiles and complication rates associated with endoscopic procedures.

Main Results:

  • Quality of life and symptom scores improved in 73-90% of patients over 36-48 months.
  • 41-77% of patients remained off reflux medication post-treatment.
  • Serious complications occurred at a low rate (0.93-2.4%), with no reported late adverse effects.

Conclusions:

  • Endoscopic antireflux treatment demonstrates durable symptom improvement and a favorable safety profile.
  • Current data support the consideration of endoscopic antireflux therapy in GERD management.
  • Minimally invasive endoscopic options provide a valuable alternative for refractory GERD patients.