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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Contemporary management of advanced renal cell carcinoma

Abhinav Khanna1, Alice Crane1, Nitin Yerram1

  • 1Cleveland Clinic Glickman Urologic & Kidney Institute, Cleveland, Ohio.

Clinical Advances in Hematology & Oncology : H&O
|August 2, 2018
PubMed

Insights

Advanced kidney cancer survival is improving due to new targeted therapies and surgical options. This review covers the latest treatments for advanced renal cell carcinoma.

Area of Science:

  • Oncology
  • Nephrology

Background:

  • Kidney cancer is a common diagnosis in the US, with many patients presenting with advanced disease.
  • Historically, outcomes for advanced kidney cancer have been poor.
  • Recent advancements are improving patient prognosis.

Purpose of the Study:

  • To provide an overview of the current treatment landscape for advanced renal cell carcinoma.
  • To highlight recent medical and surgical advances.
  • To discuss the changing treatment paradigms in advanced kidney cancer management.

Main Methods:

  • Review of recent medical and surgical advances in renal cell carcinoma treatment.
  • Analysis of emerging targeted agents and their role in treatment paradigms.
  • Evaluation of the continued importance of surgical therapy in selected patients.

Main Results:

  • Novel targeted agents have emerged, significantly altering treatment strategies for advanced renal cell carcinoma.
  • Surgical interventions remain crucial for specific patient groups.
  • Combined medical and surgical progress has led to improved survival outcomes.

Conclusions:

  • The prognosis for patients with advanced renal cell carcinoma has improved.
  • Current treatment involves a combination of novel targeted therapies and surgical approaches.
  • This review offers insights into the evolving management of advanced kidney cancer.

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