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[Synthetic Ca++-dependent proton carrier].

N V Lukoianov, O A Raevskiĭ, A S Shtepanek

    Biofizika
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    1,5-(3,3'-dimethylphosphate)diphenoxy-3-oxapentane (DDOP) enhances lipid bilayer conductivity with Ca++ and Mg++ ions. This effect, observed at pH 7.0, suggests DDOP

    Area of Science:

    • Biophysics
    • Membrane biophysics
    • Lipid bilayer studies

    Context:

    • Investigating the electrical properties of biological membranes.
    • Understanding the role of specific molecules in modulating membrane conductivity.
    • Exploring the interaction between lipids, ions, and synthetic compounds.

    Purpose:

    • To determine the influence of 1,5-(3,3 omino-dimethylphosphate)diphenoxy-3-oxapentane (DDOP) on the conductivity of lipid bilayers.
    • To elucidate the effect of divalent cations (Ca++, Mg++) and monovalent cations (K+, Na+) on DDOP-mediated conductivity.
    • To characterize the acid-base properties of DDOP and propose a structural model.

    Summary:

    • DDOP significantly increases the conductivity of common rabbit brain lipid bilayers.

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  • This conductivity enhancement is observed specifically in the presence of Ca++ and Mg++ ions, with a maximum effect at pH 7.0.
  • DDOP does not affect conductivity in the presence of K+ or Na+ ions, and its titration reveals pK values of 1.2 and 7.7, suggesting a pseudomacrocyclic structure.

    • Impact:

    • Provides insights into the mechanism of ion transport across lipid bilayers.
    • Highlights the potential of DDOP as a modulator of membrane electrical properties.
    • Suggests a role for Ca++ and Mg++ in the lipophilization of ionized DDOP forms, influencing its interaction with lipid membranes.