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[LAV virus infections in children].
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1985
Summary
This study details lymphadenopathy associated virus (LAV) infections in infants, noting clinical signs like enlarged lymph nodes and spleen. Immunological issues, including low OKT4(+) lymphocytes, were common, with transmission possibly occurring from mother to child.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
- Virology
Background:
- Lymphadenopathy associated virus (LAV) infections present unique challenges in infants.
- Understanding the clinical and immunological manifestations in neonates is crucial for early diagnosis and management.
Purpose of the Study:
- To describe the clinical signs and immunological abnormalities in infants diagnosed with LAV infection.
- To explore potential transmission routes and factors influencing disease progression in pediatric LAV cases.
Main Methods:
- Clinical case series describing ten infants with LAV infection.
- Diagnosis confirmed via immunological abnormalities, serological tests, or virus isolation.
- Analysis of clinical characteristics, ethnic/familial history, and immunological markers (e.g., OKT4(+) lymphocytes, hypergammaglobulinaemia).
Main Results:
- Clinical presentation in infants mirrored adult cases, including hepatosplenomegaly and generalized lymphadenopathy.
- Common immunological findings were decreased OKT4(+) lymphocytes and hypergammaglobulinaemia.
- Variable degrees of humoral and cellular immunodeficiency were observed; growth and weight gain were retarded.
Conclusions:
- LAV infection in early infancy suggests potential maternal-foetal transmission, though post-natal infection is possible.
- Long-term prognosis is uncertain and primarily depends on the severity of immune deficiency.
- Early identification of LAV infection in infants is critical for managing potential long-term health outcomes.