Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

565
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
565
Relative Risk01:12

Relative Risk

2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Responses to Salt Stress02:02

Responses to Salt Stress

14.6K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.6K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.7K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.9K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Multiscale heterogeneity of atypical functional connectivity in autism.

Nature. Mental health·2026
Same author

"You're the child I never wanted": an interpretative phenomenological analysis about the invisible struggle of families in crisis raising a child with persistent and severe regulatory problems.

BMC psychology·2026
Same author

Social dysfunction and default mode network functional integrity in neuropsychiatric disorders: A cross-disorder replication and generalization study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same author

Changes in human skull bone marrow during pregnancy and postpartum: an exploratory case report.

BMC pregnancy and childbirth·2026
Same author

Factors Contributing to Short-Term Structural Variability in a Longitudinal MRI Dataset.

Human brain mapping·2026

Related Experiment Video

Updated: Feb 7, 2026

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

21.5K

Prenatal stress and the developing brain: Risks for neurodevelopmental disorders.

Bea R H van den Bergh1, Robert Dahnke2, Maarten Mennes3

  • 1University of Leuven.

Development and Psychopathology
|August 3, 2018
PubMed
Summary

Prenatal stress impacts offspring brain development, affecting behavior and increasing disorder risk. Current brain imaging measures need validation for predicting neurodevelopmental disorders, necessitating longitudinal studies.

More Related Videos

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.8K
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

728

Related Experiment Videos

Last Updated: Feb 7, 2026

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

21.5K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.8K
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

728

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Medical Imaging

Background:

  • The prenatal period is critical for preventing neurodevelopmental and psychiatric disorders.
  • Understanding the pathophysiological mechanisms of these disorders is challenging.
  • Prenatal brain development research offers new insights.

Purpose of the Study:

  • To review current research on prenatal brain development.
  • To explore the impact of prenatal stress on offspring brain structure and function.
  • To assess the utility of brain imaging measures in predicting neurodevelopmental disorders.

Main Methods:

  • Review of (epi)genetic research, neuroscience, imaging techniques, physical modeling, and computational simulations.
  • Analysis of studies on prenatal exposure to maternal distress and offspring brain development.
  • Examination of structural and functional brain imaging data.

Main Results:

  • Prenatal distress affects offspring brain development from birth into adulthood.
  • Structural and functional changes observed in key brain regions (prefrontal, parietal, temporal lobes, cerebellum, hippocampus, amygdala).
  • Alterations in amygdalar-thalamus and intrinsic brain networks (default mode, attentional) are noted, impacting development and disorder susceptibility.

Conclusions:

  • Observed brain changes are linked to behavioral, cognitive, and emotional development, and disorder susceptibility.
  • Current brain imaging measures lack validated predictive accuracy for neurodevelopmental disorders.
  • Prospective, long-term longitudinal studies are needed to validate brain measures as mediators between prenatal stress and offspring outcomes.